Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Human MCP Chemokine Cluster

  • Elena Farmaki
  • Ioulia Chatzistamou
  • Hippokratis Kiaris
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101562

Synonyms

 I-309;  MCP-1;  MCP-3;  MCP-2;  Eotaxin-1;  MCP-4

Historical Background

Chemokines are small chemotactic cytokines that promote directional cell movement and originally were shown to regulate inflammation. By now the superfamily of chemokines and their receptors consists of 50 chemokines and 19 receptors (Zlotnik et al. 2006). Chemokines are classified into four groups CC, CXC, C, and CX3C, based on the position of the conserved cysteines in the amino-terminal domain. They bind to G-coupled protein receptors, with one ligand usually binding to more than one receptor and with the receptors exhibiting high affinity for more than one ligand (Rollins 1997). The chemokine superfamily is characterized, besides the low molecular mass (8–10 kDa) and the four conserved cysteines, by the ability of its members to bind heparin. The major chemokine clusters are the CC and the CXC, with the first originally identified as chemoattractant for monocytes and the latter for neutrophils. The...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Elena Farmaki
    • 1
  • Ioulia Chatzistamou
    • 2
  • Hippokratis Kiaris
    • 3
    • 4
  1. 1.Department of Drug Discovery and Biomedical SciencesSouth Carolina College of Pharmacy, University of South CarolinaColumbiaUSA
  2. 2.Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, University of South CarolinaColumbiaUSA
  3. 3.Department of BiochemistryUniversity of Athens Medical SchoolAthensGreece
  4. 4.Department of Drug Discovery and Biomedical Sciences, University of South CarolinaColumbiaUSA