Synonyms
Cytokines
APRIL: A proliferation-inducing ligand
Synonyms: TNFSF13a; TALL-2; TRDL-1; CD256
BAFF/BLyS: B cell-activating factor of the TNF family/B lymphocyte stimulator
Synonyms: TNFSF13b; TALL-1; zTNF-4; THANK; CD257
Receptors
BCMA: B cell maturation antigen
Synonyms: TNFRSF13a; TNFRSF17; CD269
TACI: Transmembrane activator and calcium modulator and cyclophilin ligand interactor
BAFFR/BR3: BAFF receptor/BLyS receptor 3
Overview
The BAFF/BLyS family includes two cytokine ligands and three receptors, all of which are members of the TNF/TNF receptor superfamily. Members of the BLyS family play critical and varied regulatory roles among cells of the B lymphocyte lineage: they control the selection and survival of pre-immune B cells, govern aspects of selection and differentiation among activated B cells, and impact formation and survival of antibody-secreting plasma cells. General features of these ligands and receptors...
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Summary
The BLyS family of receptors and ligands plays a pivotal role in maintaining peripheral homeostasis of B cells in both mice and humans. Their influence on differentiation and maintenance of antigen-experienced subsets is also beginning to be appreciated. Apart from regulating selection and life span, the BLyS/BR3 axis is relevant in autoimmunity and is a current therapeutic target.
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Myles, A., Scholz, J.L., Cancro, M.P. (2018). BAFF/BLyS Family. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101556
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101556
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Online ISBN: 978-3-319-67199-4
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