Historical Background
The first cyclophilin (Cyp/PPIases: EC 5.2.1.8) was isolated more than three decades ago as an intracellular receptor of the immunosuppressive drug cyclosporine A (CsA) from the bovine thymocyctes (Handschumacher et al. 1984). It was not until 1989, its PPIase activity was elucidated. Cyclophilins comprise a ubiquitous set of proteins which is present across diverse genera of organisms. The single domain cyclophilin has a single cyclophilin-like domain (CLD), whereas multidomain cyclophilins also possess additional domains such as tetratricopeptide repeat (TPR), RNA recognition motif (RRM), tryptophan aspartate domain (WD40), coiled-coil domain (CCD), and internal repeats domain (RPT). Cyclophilins are involved in a myriad of physiological cellular processes, such as protein trafficking and maturation, receptor complex stabilization, apoptosis, receptor...
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Roy, S., Singh, P., Singla-Pareek, S.L., Pareek, A. (2018). Cyclophilin. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101549
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101549
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