Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

C-FLIP

  • Ahmad R. Safa
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101547

Synonyms

Integration of the Mitochondrial and Death Receptors (DRs) Pathways and Role of c-FLIP

Two major signaling pathways, the intrinsic or mitochondrial pathway and the extrinsic or cell surface DRs pathway, regulate apoptosis (Fig. 1) (Lavrik et al. 2005; Micheau and Tschopp 2003; Safa et al. 2008). In the intrinsic pathway, various anti- and pro-apoptotic members of the Bcl-2 family form an interactive network that finally regulates the release of apoptosis-triggering factors such as cytochrome c, apoptosis-inducing factors including Smac/DIABLO, HtrA2/Omi, and Endonuclease G (endoG) from the mitochondria to the cytosol (Vaux 2011; Plati et al. 2011). Upon release, cytochrome cand dATP bind to apoptotic proteinase-activating factor-1 (Apaf-1), and this complex along with adenine nucleotides forms the apoptosome and promotes procaspase-9...
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Notes

Acknowledgment

I would like to thank Dr. Mary D. Kraeszig for her editorial assistance. The work in the author’s laboratory was supported by research grants from the National Cancer Institute (CA 080734, CA 90878, and CA 101743), Department of Defense (DOD) (OC 06095), and the Indiana University Cancer Center Translational Research Acceleration Collaboration (ITRAC) initiative.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Pharmacology and ToxicologyIndiana University School of MedicineIndianapolisUSA
  2. 2.Indiana University Simon Cancer CenterIndiana University School of MedicineIndianapolisUSA