Synonyms
Historical Background
Tillett and Francis (1930) noticed that C polysaccharide of Pneumococcus precipitated in the serum of patients with lobar pneumonia. During the acute stage of the disease, precipitation test was positive, while negative shortly after recovery. This indicated that there was a substance reactive only during the acute phase of the infectious disease which was confirmed in sera taken from children in acute phase of Gram-negative bacilli by Ash (1933). Abernethy and Francis (1937) injected C carbohydrate in patients with acute phase of pneumonia and noticed specific skin reactions associated with the effect of precipitation of C polysaccharide. Abernethy and Avery (1941) showed that serum taken from humans and monkeys contained protein that has the ability to precipitate with C polysaccharide during the acute stage of various infectious diseases, but in the presence of Ca2+. Later, C...
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References
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Acknowledgments
This work is supported by grants No.173033 (to E.R.I) from the Ministry of Science, Republic of Serbia.
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Trpkovic, A., Obradovic, M., Petrovic, N., Davidovic, R., Sudar-Milovanovic, E., Isenovic, E.R. (2018). C-Reactive Protein. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101542
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101542
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