S100A13 belonging to S100 protein family was discovered in 1996 in the laboratory of Claus W. Heizmann (Wicki et al. 1996). The S100A13 gene is localized on human chromosome 1q21 in the cluster of genes coding for other S100 proteins (Ridinger et al. 1998). High levels of S100A13 expression were reported for skeletal muscle, heart, kidney, ovary, small intestine, and pancreas (Ridinger et al. 2000).
S100A13 and Nonclassical Protein Export (FGF1, IL1α, Prothymosin)
Similar to other members of S100 family, S100A13 is secreted despite the absence in its structure of a signal peptide required for translocation into the lumen of the endoplasmic reticulum (ER) (Landriscina et al. 2001). NIH3T3 cells transfected with S100A13 spontaneously release it through an unconventional ER-Golgi independent pathway (Landriscina et al. 2001). S100A13 has been detected in a brain-derived...