Axin

Song, Xiaomin; Li, Lin

doi:10.1007/978-3-319-67199-4_101525

Axin

Xiaomin Song &
Lin Li²

Reference work entry
First Online: 01 January 2018

112 Accesses

Synonyms

Axin1; Fused; PPP1R49

Historical Background

A fundamental process in embryonic development is the establishment of body axes, including the anteroposterior (A-P) axis, the dorsoventral (D-V) axis, and the left-right (L-R) axis. Back to 1940s, when signaling pathways and molecular mechanisms behind axis formation remained a mystery, a spontaneous mutation called Kinky (Fu^Ki) at the mouse Fused locus attracted attention due to its impact on a variety of developmental processes, especially on the formation of embryonic A-P axis(Gluecksohn-Schoenheimer 1949). Around 1990s, two other spontaneous alleles of the mouse Fused gene, Fused (Fu^Fu) and Knobbly (Fu^Kb), and one transgenic insertional mutant Fu^Tg1 were identified (Jacobs-Cohen et al. 1984; Perry et al. 1995; Mary et al. 1996), all showing defects in the formation of embryonic axis. These Axinnull mutants normally led to lethality at embryonic day 8–10, and in addition to causing embryonic axis duplications, they also led to...

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State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
Lin Li

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Xiaomin Song
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Department of Molecular Science and Technology, Ajou University, Suwon, Korea
Sangdun Choi

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Song, X., Li, L. (2018). Axin. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101525

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DOI: https://doi.org/10.1007/978-3-319-67199-4_101525
Published: 01 June 2018
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