Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Laminin β2

  • Yamato Kikkawa
  • Hiroshi Nishimune
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101519


Historical Background

Laminin β2 was identified as basement membrane a component in neuromuscular junctions (NMJs). Basement membranes are thin sheet-like structures that abut many cell types, including epithelial, endothelial, fat, muscle, and peripheral nerve cells. They influence tissue compartmentalization and cellular phenotypes during developmental and regenerative processes. Although a pure basement membrane was necessary to investigate its composition, it was difficult to purify the basement membrane from various tissues, including NMJs. The Matrigel matrix, an extract derived from mouse Engelbreth-Holm-Swarm sarcoma, is composed of type IV collagen, laminin, nidogen, and perlecan, which are the major components of basement membranes. Therefore, the Matrigel matrix has been used as a reconstituted basement membrane. Although Matrigel has significantly advanced many studies of basement membranes,...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Laboratory of Clinical BiochemistryTokyo University of Pharmacy and Life SciencesTokyoJapan
  2. 2.Department of Anatomy and Cell BiologyUniversity of Kansas, School of MedicineKansas CityUSA