Synonyms
RCAN1 (Regulator of calcineurin 1; DSCR1, Down syndrome critical region gene 1; Dscr1; ADAPT78; MCIP1, Modulatory calcineurin-interacting protein1; Calcipressin 1, Csp1, CALP1; RCN-1, RCN1, Rcn1p; CBP1, calcineurin binding protein1; Nebula, nla; Sarah, sra); RCAN2 (Regulator of calcineurin 2; Dscr1l1, Dscr1-like 1; MCIP2, Modulatory calcineurin-interacting protein 2; Calcipressin 2; Thyroid Hormone-Responsive Protein ZAKI-4); RCAN3 (Regulator of calcineurin 3; DSCR1L2, DSCR1-like 2; Dscr1l2; Calcipressin 3)
Historical Background
The protein family of the regulators of calcineurin (RCANs), previously termed as DSCR, MCIP, or calcipressins among other names, has been shown to function as regulators of the calcium-calmodulin regulated phosphatase calcineurin. The gene encoding for the first RCAN protein was cloned more than 20 years ago and named DSCR1, as it was identified in the Down syndrome critical region, which encoded a proline-rich protein highly expressed in the human...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S. Down’s syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature. 2009;459:1126–30.
Cao X, Kambe F, Miyazaki T, Sarkar D, Ohmori S, Seo H. Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors. Biochem J. 2002;367:459–66.
Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, Olson EN, Zhang Z, Williams RS, Gerber HP, Perez-Riba M, Seo H, Cao X, Klee CB, Redondo JM, Maltais LJ, Bruford EA, Povey S, Molkentin JD, McKeon FD, Duh EJ, Crabtree GR, Cyert MS, de la Luna S, Estivill X. Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J. 2007;21:3023–8.
Ermak G, Hench KJ, Chang KT, Sachdev S, Davies KJ. Regulator of calcineurin (RCAN1-1 L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro. J Biol Chem. 2009;284(18):11845–53.
Ermak G, Pritchard MA, Dronjak S, Niu B, Davies KJ. Do RCAN1 proteins link chronic stress with neurodegeneration? FASEB J. 2011;25:3306–11.
Facchin F, Vitale L, Bianconi E, Piva F, Frabetti F, Strippoli P, Casadei R, Pelleri MC, Piovesan A, Canaider S. Complexity of bidirectional transcription and alternative splicing at human RCAN3 locus. PLoS One. 2011;6:e24508.
Fuentes JJ, Pritchard MA, Planas AM, Bosch A, Ferrer I, Estivill X. A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. Hum Mol Genet. 1995;4:1935–44.
Fuentes JJ, Genesca L, Kingsbury TJ, Cunningham KW, Perez-Riba M, Estivill X, de la Luna S. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum Mol Genet. 2000;9:1681–90.
Genesca L, Aubareda A, Fuentes JJ, Estivill X, De La Luna S, Perez-Riba M. Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. Biochem J. 2003;374:567–75.
Kingsbury TJ, Cunningham KW. A conserved family of calcineurin regulators. Genes Dev. 2000;14:1595–604.
Liu H, Wang P, Weihong S, Sun X. Degradation of regulator of calcineurin 1(RCAN1) is mediated by both chaperone mediated autophagy and ubiquitin proteosome pathways. FASEB J. 2009;23(10):3383–92.
Martinez-Hoyer S, Sole-Sanchez S, Aguado F, Martinez-Martinez S, Serrano-Candelas E, Hernandez JL, Iglesias M, Redondo JM, Casanovas O, Messeguer R, Perez-Riba M. A novel role for an RCAN3-derived peptide as a tumor suppressor in breast cancer. Carcinogenesis. 2015;36:792–9.
Minami T. Calcineurin-NFAT activation and DSCR-1 auto-inhibitory loop: how is homoeostasis regulated? J Biochem. 2014;155:217–26.
Miyazaki T, Kanou Y, Murata Y, Ohmori S, Niwa T, Maeda K, Yamamura H, Seo H. Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts. J Biol Chem. 1996;271:14567–71.
Mulero MC, Aubareda A, Schluter A, Perez-Riba M. RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression. Biochim Biophys Acta. 2007;1773:330–41.
Ryeom S, Baek KH, Rioth MJ, Lynch RC, Zaslavsky A, Birsner A, Yoon SS, McKeon F. Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth. Cancer Cell. 2008;13(5):420–31.
Serrano-Candelas E, Farre D, Aranguren-Ibanez A, Martinez-Hoyer S, Perez-Riba M. The vertebrate RCAN gene family: novel insights into evolution, structure and regulation. PLoS One. 2014;9:e85539.
Serrano-Candelas E, Aleman MG, Sole-Sanchez S, Aubareda A, Martinez-Hoyer S, Adan J, Aranguren-Ibanez A, Pritchard MA, Soldevila G, Perez-Riba M. RCAN1 and 3 proteins regulate thymic positive selection. Biochem Biophys Res Commun. 2015;460(2):295–301.
Valdor R, Mocholi E, Botbol Y, Guerrero-Ros I, Chandra D, Koga H, Gravekamp C, Cuervo AM, Macian F. Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation. Nat Immunol. 2014;15:1046–54.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Guerrero-Ros, I., Valdor, R. (2018). RCAN. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101514
Download citation
DOI: https://doi.org/10.1007/978-3-319-67199-4_101514
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences