MAVS-Mitochondrial Antiviral Signaling Protein
Adaptor proteins are crucial members of signaling cascades that bind to multiple pattern recognition receptors to streamline the inflammatory response. One such adaptor molecule is MAVS (also known as IPS1, VISA, or CARDIF), which is present downstream of RIG-I and MDA-5, cytosolic sensors of viral genomic material (Seth et al. 2005). In the year 2005, several groups independently identified an adaptor protein that controls activation of IKK and TBK1/IKKε downstream of RIG-I. This adaptor molecule was named MAVS (Seth et al. 2005), IPS-1 (Kawai et al. 2005), VISA (Xu et al. 2005), or CARDIF (Meylan et al. 2005). However, MAVS is now the standard nomenclature accepted in the scientific community. Upon activation, MAVS initiates downstream signaling cascades leading to the production of inflammatory cytokines, antimicrobial peptides, and activation of several transcription factors (Li et al. 2011). Its importance is now recognized not only in viral infection but...
- Dann A, Poeck H, Croxford AL, Gaupp S, Kierdorf K, Knust M, Pfeifer D, Maihoefer C, Endres S, Kalinke U, Meuth SG, Wiendl H, Knobeloch KP, Akira S, Waisman A, Hartmann G, Prinz M. Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS. Nat Neurosci. 2011;15(1):98–106.CrossRefPubMedGoogle Scholar
- Goritzka M, Makris S, Kausar F, Durant LR, Pereira C, Kumagai Y, Culley FJ, Mack M, Akira S, Johansson C. Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes. J Exp Med. 2015;212(5):699–714.PubMedPubMedCentralCrossRefGoogle Scholar
- Li XD, Chiu YH, Ismail AS, Behrendt CL, Wight-Carter M, Hooper LV, Chen ZJ. Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis. Proc Natl Acad Sci USA. 2011;108(42):17390–5.PubMedPubMedCentralCrossRefGoogle Scholar
- McDonald B, Pittman K, Menezes GB, Hirota SA, Slaba I, Waterhouse CC, Beck PL, Muruve DA, Kubes P. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science. 2010;330(6002):362–6. https://doi.org/10.1126/science.1195491. Erratum in: Science. 2011;331(6024):1517.CrossRefGoogle Scholar
- Su YJ, Cheng TT, Chen CJ, Chang WN, Tsai NW, Kung CT, Wang HC, Lin WC, Huang CC, Chang YT, Su CM, Chiang YF, Cheng BC, Lin YJ, Lu CH. Investigation of the caspase-dependent mitochondrial apoptotic pathway in mononuclear cells of patients with systemic Lupus erythematosus. J Transl Med. 2014;12:303.PubMedPubMedCentralCrossRefGoogle Scholar