RIG-I (Retinoic Acid Inducible Gene-I)
RIG-I (retinoic acid-inducible gene-I, DDX58) is the founding member of the family of RIG-I like receptors (RLRs) that have been demonstrated to have a role in antiviral immunity. It was first reported in Pig by Zhang et al. as a helicase induced during reproductive and respiratory syndrome virus replication (Zhang et al. 2000). In 2004, Yoneyama et al. identified RIG-I as a sensor of viral RNA using a cDNA library screen of molecules that potently enhanced type-I IFN production in response to dsRNA molecules (Yoneyama et al. 2004). RIG-I is a cytoplasmic pattern recognition receptor that belongs to the class of ATP-dependent helicases. This class also includes MDA5 and LGP2. RIG-I is described to have three different domains each with different functions. It has a tandem CARD domain at the N-terminus, a central helicase/ATPase domain, and a C-terminal domain (CTD). The C-terminal domain or...
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