Synonyms
Chondroma of soft parts; Extraskeletal chondroma; Soft tissue chondroma
Definition
Mediastinal chondroma is a benign mesenchymal neoplasm composed of hyaline cartilage arising as an extraosseal mass in mediastinum. Primary chondromas arising in mediastinum most probably develop from embryonal pluripotent cells or through connective tissue metaplasia, as suggested by Macchiarini and Ostertag in 2004.
Clinical Features
Incidence
True primary mediastinal extraosseous chondromas are extremely rare.
Age
There are no data about primary mediastinal chondromas, but soft-tissue chondromas in general occur in middle-aged patients and are rare in children.
Sex
There are no data specific for primary mediastinal chondromas, but soft-tissue chondromas are more common in men than women (3:2).
Site
Most common in anterior mediastinum but can also appear in posterior mediastinum.
Treatment
Although histologically they are benign lesions, they tend to have malignant clinical course, and local...
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References and Further Reading
Bridge, J. A., Bhatia, P. S., Anderson, J. R., & Neff, J. R. (1993). Biologic and clinical significance of cytogenetic and molecular cytogenetic abnormalities in benign and malignant cartilaginous lesions. Cancer Genetics and Cytogenetics, 69, 79–90.
Dahlén, A., Mertens, F., Rydholm, A., Brosjö, O., Wejde, J., Mandahl, N., & Panagopoulos, I. (2003). Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. Modern Pathology, 16, 1132–1140.
Goldblum, J. R., Folpe, A. L., & Weiss, S. W. (2014). Cartilaginous and osseous soft tissue tumors. In J. R. Goldblum, A. L. Folpe, & S. W. Weiss (Eds.), Enzinger and Weiss’s soft tissue tumors (pp. 918–922). Philadelphia: Elsevier Saunders.
Macchiarini, P., & Ostertag, H. (2004). Uncommon primary mediastinal tumours. Lancet Oncology, 5, 107–118.
Rosenberg, A. E., & Mandahl, N. (2013). Soft-tissue chondroma. In C. D. M. Fletcher, J. A. Bridge, P. C. W. Hogendoorn, & F. Mertens (Eds.), WHO classification of tumours of soft tissue and bone (pp. 160–161). Lyon: International Agency for Research on Cancer.
Shrivastava, V., Vundavalli, S., Smith, D., & Tennant, D. (2006). A chondroma of the anterior mediastinum. Clinical Radiology, 61, 1065–1066.
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Brcic, L. (2018). Chondroma, Mediastinal. In: Allen, T.C., Suster, S. (eds) Pathology of the Pleura and Mediastinum. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-66796-6_9
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DOI: https://doi.org/10.1007/978-3-319-66796-6_9
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