Castleman Disease, Mediastinal
Angiofollicular lymph node hyperplasia; Angiomatous lymphoid hamartoma; Benign giant lymphoma; Giant lymph node hyperplasia
Castleman disease is a relatively rare lymphoproliferative disorder that includes a heterogeneous group of diseases with protean clinical and morphologic features. The various types of Castleman disease comprise unicentric and multicentric variants, which somewhat overlap with the hyaline vascular and plasma cell morphologic subtypes, respectively.
The prevalence of Castleman disease is not well established. There are several large case series describing different variants of the disease in immunocompetent and HIV patients, and certain data can be extracted from those studies. In the United States, it was estimated that there are between 30,000 and 100,000 cases (Casper 2005).
The unicentric, hyaline vascular Castleman disease has a median age of presentation in the fourth decade, although it can occur in a range...