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Pathology of the Pleura and Mediastinum pp 33–39Cite as

B-Cell Lymphoma, Mediastinal, Diffuse, and Large

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Primary mediastinal (thymic) large B-cell lymphoma

Definition

Primary mediastinal (thymic) large B-cell lymphoma (PMLBCL) is a diffuse large B-cell lymphoma (DLBCL) of putative thymic origin, arising in the anterior mediastinum and showing distinct clinical and pathologic features (Cazals-Hatem et al. 1996; Johnson and Davies 2008).

Clinical Features

  • Incidence

    PMLBCL is an uncommon neoplasm, representing 2–4% of non-Hodgkin lymphomas and approximately 6% of all adult lymphomas.

  • Age

    Young adults are most commonly affected, with a median age of presentation of 35 years, although the age range is fairly broad (15–73 years, in a series of 29 cases).

  • Sex

    There is a female predominance (male to female = 1:2) in those diagnosed with PMLBCL.

  • Site

    Clinically, patients present with a bulky, anterior mediastinal mass, which commonly extends to the pericardium, pleura, or lung and causes superior vena cava invasion or compression. There is very rare systemic, lymph node, CNS, and bone...

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References and Further Reading

  • Cazals-Hatem, D., Lepage, E., Brice, P., Ferrant, A., d'Agay, M. F., Baumelou, E., et al. (1996). Primary mediastinal large B-cell lymphoma. A clinicopathologic study of 141 cases compared with 916 nonmediastinal large B-cell lymphomas, a GELA (“Groupe d’Etude des Lymphomes de l’Adulte”) study. American Journal of Surgical Pathology, 20(7), 877–888.

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  • Johnson, P. W., & Davies, A. J. (2008). Primary mediastinal B-cell lymphoma. Hematology/American Society of Hematology Education Program, 2008, 349–358.

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  • Rieger, M., Osterborg, A., Pettengell, R., White, D., Gill, D., Walewski, J., et al. (2011). Primary mediastinal B-cell lymphoma treated with CHOP-like chemotherapy with or without rituximab: results of the Mabthera International Trial Group Study. Annals of Oncology, 22(3), 664–670.

    Article  CAS  PubMed  Google Scholar 

  • Savage, K. J., Al-Rajhi, N., Voss, N., Paltiel, C., Klasa, R., Gascoyne, R. D., et al. (2006). Favorable outcome of primary mediastinal large B-cell lymphoma in a single institution: the British Columbia experience. Annals of Oncology, 17(1), 123–130.

    Article  CAS  PubMed  Google Scholar 

  • Steidl, C., & Gascoyne, R. D. (2011). The molecular pathogenesis of primary mediastinal large B-cell lymphoma. Blood, 118(10), 2659–2669.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI, 53226, USA

    Horatiu Olteanu

  2. Department of Pathology, Mayo Clinic, Rochester, MN, USA

    Horatiu Olteanu

Authors
  1. Horatiu Olteanu
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Corresponding author

Correspondence to Horatiu Olteanu .

Editor information

Editors and Affiliations

  1. Department of Pathology, The University of Mississippi Medical School, The University of Mississippi Medical Center, Jackson, MS, USA

    Timothy Craig Allen

  2. Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA

    Saul Suster

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Cite this entry

Olteanu, H. (2018). B-Cell Lymphoma, Mediastinal, Diffuse, and Large. In: Allen, T.C., Suster, S. (eds) Pathology of the Pleura and Mediastinum. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-66796-6_6

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  • DOI: https://doi.org/10.1007/978-3-319-66796-6_6

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-66795-9

  • Online ISBN: 978-3-319-66796-6

  • eBook Packages: MedicineReference Module Medicine

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