Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Synovial Sarcoma, Mediastinal

  • Giovanni Falconieri
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-66796-6_52

Definition

Primary synovial sarcoma is a distinctive mesenchymal neoplasm usually occurring in the limbs of young patients; however, intrathoracic forms are not unusual, and cases occurring in the mediastinum have been described in independent series (Hartel et al. 2007; Moran et al. 1994; Suster and Moran 2005). Although microscopically identical to synovial sarcoma arising in the somatic soft tissues, mediastinal lesions may be confused with many intrathoracic mesenchymal proliferations. In addition, mediastinal synovial sarcomas (MSSs) appear to occur in younger patients and to pursue a more aggressive course. Infiltration of the adjacent structures is common and makes radical excision of the tumor difficult.

Clinical Features

  • Incidence

    Being very rare, with limited reported cases, the incidence of MSS is difficult to estimate. Synovial sarcoma is, however, one of the most common intrathoracic sarcomas.

  • Age

    Most patients were between the second and fifth decade group; however, cases...

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References and Further Reading

  1. Fisher, C., Montgomery, E., & Healy, V. (2003). Calponin and h-caldesmon expression in synovial sarcoma; the use of calponin in diagnosis. Histopathology, 42(6), 588–593.CrossRefPubMedGoogle Scholar
  2. Hartel, P. H., Fanburg-Smith, J. C., Frazier, A. A., Galvin, J. R., Lichy, J. H., Shilo, K., et al. (2007). Primary pulmonary and mediastinal synovial sarcoma: A clinicopathologic study of 60 cases and comparison with five prior series. Modern Pathology, 20(7), 760–769.CrossRefPubMedGoogle Scholar
  3. Moran, C. A., Suster, S., Perino, G., Kaneko, M., & Koss, M. N. (1994). Malignant smooth muscle tumors presenting as mediastinal soft tissue masses. A clinicopathologic study of 10 cases. Cancer, 74(8), 2251–2260 [Review].CrossRefPubMedGoogle Scholar
  4. Suster, S., & Moran, C. A. (2005). Primary synovial sarcomas of the mediastinum: A clinicopathologic, immunohistochemical, and ultrastructural study of 15 cases. American Journal of Surgical Pathology, 29(5), 569–578.CrossRefPubMedGoogle Scholar
  5. Terry, J., Saito, T., Subramanian, S., Ruttan, C., Antonescu, C.R., Goldblum, J.R., et al. (2007). TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies, American Journal of Surgical Pathology, 31(2), 240–246.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pathology, School of MedicineUniversity of TriesteTriesteItaly