Wegener’s Granulomatosis, Pleural
GPA; Granulomatosis with polyangiitis; WG
Wegener’s granulomatosis (WG) is a necrotizing and granulomatous vasculitic syndrome that affects small- to medium-sized vessels in a characteristic triad of organs: the upper respiratory tract (e.g., sinuses), the lungs, and the kidneys. In widespread WG, other organs may be involved as well, including the skin, the eyes, and rarely the heart. WG may also be limited and not involve the entire triad of organ systems. Thus, the presentation may be variable.
Clinical symptoms at presentation typically include sinusitis, fever, night sweats, and malaise. Other signs and symptoms may include epistaxis, weight loss, flank pain, hematuria, and cough. With further workup, bilateral nodular and cavitary infiltrates will be present in up to 95% of patients, and 80% of patients will have evidence of renal disease (Kumar et al. 2005). In 12–20% of cases, a unilateral or bilateral pleural effusion caused by renal failure or by primary...
References and Further Reading
- Kumar, V., et al. (2005). Robbins and cotran pathologic basis of disease. Philadelphia: Elsevier Saunders.Google Scholar