Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Synovial Sarcoma, Pleural

  • Michael P. Sedrak
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-66796-6_391

Synonyms

Malignant synovioma; Synovial cell sarcoma; Synovioblastic sarcoma

Definition

Synovial sarcoma is a malignant mesenchymal spindle cell tumor, which can display areas of epithelial differentiation. Synovial sarcoma in the pleura or lung is often a metastasis from an extrapulmonary site, but can occur in the absence of a primary tumor elsewhere.

Clinical Features

  • Incidence

    Primary pleural synovial sarcoma is a rare tumor with fewer than 50 cases reported.

  • Age

    Primary pleural synovial sarcoma usually presents in young- to middle-aged adults.

  • Sex

    No gender predilection has been observed.

  • Site

    Primary synovial sarcoma of the pleura can involve the upper or lower lung lobes.

  • Treatment

    A multimodal treatment approach including surgical resection, chemotherapy, and radiotherapy is recommended.

  • Outcome

    Prognosis is generally poor with nearly half of patients dying of disease within 2 years; however, if the lesion is localized, the prognosis appears to be significantly better than with...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Aubry, M. C., Bridge, J. A., Wickert, R., & Tazelaar, H. D. (2001). Primary monophasic synovial sarcoma of the pleura: Five cases confirmed by the presence of SYT-SSX fusion transcript. The American Journal of Surgical Pathology, 25, 776–781.CrossRefPubMedGoogle Scholar
  2. Eilber, F. C., & Dry, S. M. (2008). Diagnosis and management of synovial sarcoma. Journal of Surgical Oncology, 97, 314–320.CrossRefPubMedGoogle Scholar
  3. Gaertner, E., Zeren, E. H., Fleming, M. V., Colby, T. V., & Travis, W. D. (1996). Biphasic synovial sarcomas arising in the pleural cavity: A clinicopathologic study of five cases. The American Journal of Surgical Pathology, 20, 36–45.CrossRefPubMedGoogle Scholar
  4. Lino-Silva, L. S., Flores-Gutiérrez, J. P., Vilches-Cisneros, N., & Domínguez-Malagón, H. R. (2011). TLE1 is expressed in the majority of primary pleuropulmonary synovial sarcomas. Virchows Archiv, 459(6), 615–621.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyUniversity of Texas Medical BranchGalvestonUSA