Histologic Changes of Pleurodesis
Obliteration of pleural cavity; Pleurosclerosis; Scarification of pleura
Pleurodesis, from the Greek pleura and desis (binding together), is the artificial production of adhesions between the parietal and visceral pleura for the treatment of a persistent pneumothorax or severe pleural effusion, and mesothelioma, according to the 29th edition of Dorland’s Illustrated Medical Dictionary.
Pleurodesis has been performed since the beginning of the twentieth century, and various agents have been used. However, the search for the ideal sclerosing agent continues.
Among the chemicals that have been used to produce pleurodesis are the following: talc, Corynebacterium parvum, macrolides, quinolones, doxycycline, tetracycline (TCN), and bleomycin. Recently, biological mediators of inflammation [transforming growth factor β(TGF-β) and interferon] have been found to be effective in the production of pleurodesis. The use of povidone-iodine, autologous blood, and polidocanol has...