Collagen Vascular Disease, Pleural
Connective tissue disorders; Lupus effusion; Lupus pleuritis; Rheumatic pleuritis
Collagen vascular diseases are a complex group of systemic inflammatory diseases generally considered autoimmune in etiology. Current data supports that these result from the interplay of genetic factors, autoantibodies, immune complexes, hormones, and other factors.
This disease group includes systemic lupus erythematosus (hyperlink), rheumatoid arthritis (hyperlink), progressive systemic sclerosis (hyperlink), polymyositis/dermatomyositis (hyperlink), Sjögren syndrome (hyperlink), overlap syndromes such as mixed connective tissue disease (hyperlink), undifferentiated connective tissue disease, and others.
Many collagen vascular diseases involve pulmonary parenchyma with resulting significant morbidity (hyperlink). They also involve the pleura, manifesting as pleuritis with or without pleural effusion. Pleural involvement by these diseases is variable in severity, and its onset may...
References and Further Reading
- Gaubitz, M. (2008). Epidemiology of connective tissue disorders. Rheumatology, 47, 234–235.Google Scholar