Primary Thymic Epithelial Neoplasms
Thymic carcinoma; Thymoma
Primary thymic epithelial neoplasms are defined as tumors that arise from neoplastic transformation of thymic epithelial cells and encompass a wide spectrum of primary thymic neoplasms that may range from very low-grade to highly aggressive malignant tumors.
The concept that this family of tumors represents a closely related spectrum of lesions that shares a common progenitor cell is supported by the occurrence of transitions and transformations of low-grade thymic epithelial neoplasms into higher-grade tumors both in primary lesions and at metastatic sites.
The low-grade end of the spectrum for these tumors has traditionally been designated as thymoma; the high-grade end of the spectrum has been traditionally placed into a separate clinical category and designated by convention as thymic carcinoma. In recent years, it has become increasingly recognized that tumors showing borderline clinical and pathological features between these two ends...
References and Further Reading
- Suster, S., & Moran, C. A. (2009). The mediastinum, chapter 17. In N. Weidner, R. Cote, S. Suster, & L. M. Weiss (Eds.), Modern pathology (2nd ed.). Philadelphia: Saunders-Elsevier, p 455.Google Scholar
- Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. G. (2015). WHO classification of tumors of the lung, pleura, thymus and heart. Lyon: IARC Press.Google Scholar