Lymphohematopoietic Stem Cells and Their Aging

  • Hanna Leins
  • Hartmut GeigerEmail author
Living reference work entry


One underlying contribution to aging-associated immune remodeling might be aging of the stem cell that all immune cells are derived from, the hematopoietic stem cell (HSC). A defined canonical set of phenotypic and functional features separates young from aged HSCs. Molecular mechanisms that contribute to aging of HSCs have been recently identified and comprise stem cell-intrinsic mechanisms as well as influences stemming from an aged stem cell niche. Aging of stem cells is reversible, and rejuvenation of aged HSCs might contribute to healthy aging.


Hematopoietic stem cell Aging Immune remodeling Niche Rejuvenation 


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Internal Medicine IUniversity Hospital of UlmUlmGermany
  2. 2.Institute of Molecular MedicineUlm UniversityUlmGermany
  3. 3.Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical CenterCincinnatiUSA

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