Lymphocyte Subtypes and Functions in Centenarians as Models for Successful Aging
Several cell subsets participate to the immune response, and their close interplay is fundamental for the successful elimination of harmful pathogens. Immune system undergoes a progressive and profound remodeling of its functions with aging. This process is evidenced by a continuous change in the relative percentages, absolute number, and functionality of the subsets of lymphocytes that ultimately form the immune system.
In this chapter, we describe the main changes in lymphocyte subtypes and functions that occur with age, paying particular attention to centenarians, exceptional individuals who reach the extreme limits of human life in good state of health. A particular emphasis is dedicated to changes observed in particular subsets, like regulatory T cells, invariant natural killer T cells, or mucosal-associated invariant T cells, whose role in many chronic inflammatory diseases or autoimmune diseases has been recently evidenced.
KeywordsCentenarians Polychromatic flow cytometry Successful aging Treg
Sara De Biasi is an International Society for Advancement of Cytometry (ISAC) Marylou Ingram Scholar.
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