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Autophagy and T Cell Aging

  • Fernando Macian
Living reference work entry

Abstract

Autophagy involves the degradation and recycling of cytosolic material in the lysosomes. At least three general forms of autophagy, macroautophagy, microautophagy, and chaperon-mediated autophagy, have been described in mammalian cells and are defined by the mechanisms utilized by cytosolic components to reach the lysosomal lumen. Autophagy plays a central role in a wide array of cellular functions that range from the maintenance of cell homeostasis and quality control to the modulation of the response to stress or the regulation of programs of cell activation and differentiation. A decline in the activity of different forms of autophagy with age has been described in many cells types and tissues, including cells of the immune system. This chapter will provide an overview of the role that different forms of autophagy play in the regulation of the T cell response and will analyze how a dysregulation of those forms of autophagy may underlie the functional defects that characterize T cell responses in old organisms.

Keywords

Macroautophagy Chaperone-mediated autophagy T cell immunosenescence Mitochondria T cell metabolism T cell homeostasis 

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Pathology and Institute for Aging ResearchAlbert Einstein College of MedicineBronxUSA

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