Breast Pathology

2020 Edition
| Editors: Anna Sapino, Janina Kulka

Mucocele-like Lesion

  • Janina KulkaEmail author
Reference work entry


Mucocele-like tumor


Rosen, who first described these lesions in 1986, gave the following definition: “mucin containing cysts lined by flat or low cubical epithelium with or without extravasated mucin” (Rosen 1986).

Clinical Features

  • Incidence

    Since the first description by Rosen in 1986, single case reports or relatively small series have been published. With the introduction of screening programs, the incidence increased due to the associated microcalcifications. The incidence of MCLLs is very low, ranging from 0.25% (Jaffer et al. 2011) to <1% (102 MCLL cases in a population of 13,412 women with biopsy proven benign breast disease) (Meares et al. 2016).

  • Age

    Since MCLLs are very often associated with microcalcifications and are discovered mainly on screening mammograms, the mean age reported is 53–55 years.

  • Sex

    No MCLLs have been described in male patients to date.

  • Site

    No specific site in the breast has been described.

  • Imaging

    The majority of these lesions are...

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References and Further Reading

  1. Dash, I., Dessauvagie, B., Hardie, M., Saunders, C., & Wilie, E. (2017). Mucocele-like lesions: Is surgical excision still necessary. Clinical Radiology, 72, 992.e1–992.e6.CrossRefGoogle Scholar
  2. Davies, J. D., Kutt, E., Kulka, J., Farndon, J. R., & Webb, A. J. (1995). Mucocoele-like lesions detected by the mammographic presence of suspicious clustered microcalcifications. The Breast, 5, 135–140.CrossRefGoogle Scholar
  3. Jaffer, S. J., Bleiweiss, I. J., & Nagi, C. S. (2011). Benign mucocele-like lesions of the breast: Revisited. Modern Pathology, 24, 683–687.PubMedCrossRefGoogle Scholar
  4. Kim, D., Jung, W.-H., & Koo, J. S. (2012). Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast. Pathobiology, 79, 144–153.PubMedCrossRefPubMedCentralGoogle Scholar
  5. Meares, A. L., Frank, R. D., Degnim, A. C., Vierkant, R. A., Frost, M. H., Hartmann, L. C., Winham, S. J., & Visscher, D. W. (2016). Mucocele-like lesions of the breast: A cliniical outcome and histologic analysis of 102 cases. Human Pathology, 49, 33–38.PubMedCrossRefPubMedCentralGoogle Scholar
  6. Rakha, E. A., Shaaban, A. M., Asma Haider, S., Jankins, J., Menon, S., Johnson, C., Yamaguchi, R., Murphy, A., Liston, J., Cornford, E., Hamilton, L., James, J., Ellis, I. O., & Lee, A. H. S. (2013). Histopathology, 62, 894–898.PubMedCrossRefPubMedCentralGoogle Scholar
  7. Rosen, P. P. (1986). Mucocele-like tumors of the breast. American Journal of Surgical Pathology, 10, 464–469.PubMedCrossRefPubMedCentralGoogle Scholar
  8. Tan, P. H., Tse, G. M. K., & By, B. H. (2008). Mucinous breast lesions: Diagnostic challenges. Journal of Clinical Pathology, 6, 11–19.Google Scholar
  9. Torous, V. F., Schnitt, S. J., & Collins, L. C. (2017). Benign breast lesions that mimic malignancy. Pathology, 49, 181–196.PubMedCrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.2nd Department of PathologySemmelweis UniversityBudapestHungary