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Malignant Adenomyoepithelioma (M-AME)

  • Reference work entry
  • First Online:
Breast Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Adenomyoepithelial carcinoma; Adenomyoepithelioma with malignant transformation; Carcinoma ex-adenomyoepithelioma; Carcinoma ex-pleomorphic adenoma; Epithelial-myoepithelial carcinoma

Definition

M-AME is a malignant neoplasm of the breast that is arising within or intimately associated with a clinically and/or histologically definable benign adenomyoepithelioma or is a malignant neoplasm showing concurrent epithelial and myoepithelial differentiation. The entity of histologically benign or borderline/atypical AME associated with metastases (Nadelman et al. 2006) is not included in this definition.

Classification of M-AME

  • Epithelial-myoepithelial carcinoma (EMEC)

  • AME containing in situ carcinoma

  • AME associated with invasive carcinoma (carcinoma ex-AME):

    • Breast carcinoma of no special type (NST)

    • Invasive lobular carcinoma

    • Carcinoma of special types

      • Squamous or adenosquamous

      • Spindle cell

      • Carcinosarcoma

      • Metaplastic matrix producing

      • Myoepithelial carcinoma

Clinical Features

...

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References and Further Reading

  • Ali, R. H., & Hayes, M. M. (2012). Combined epithelial-myoepithelial lesions of the breast. Surgical Pathology Clinics, 5(3), 661–699.

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  • Angèle, S., Jones, C., Reis Filho, J. S., Fulford, L. G., Treilleux, I., Lakhani, S. R., & Hall, J. (2004). Expression of ATM, p53, and the MRE11-Rad50-NBS1 complex in myoepithelial cells from benign and malignant proliferations of the breast. Journal of Clinical Pathology, 57(11), 1179–1184.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gatalica, Z., Velagaleti, G., Kuivaniemi, H., Tromp, G., Palazzo, J., Graves, K. M., Guigneaux, M., Wood, T., Sinha, M., & Luxon, B. (2005). Gene expression profile of an adenomyoepithelioma of the breast with a reciprocal translocation involving chromosomes 8 and 16. Cancer Genetics and Cytogenetics, 156(1), 14–22.

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  • Han, B., Mori, I., Nakamura, M., Wang, X., Ozaki, T., Nakamura, Y., & Kakudo, K. (2006). Myoepithelial carcinoma arising in an adenomyoepithelioma of the breast: Case report with immunohistochemical and mutational analysis. Pathology International, 56(4), 211–216.

    Article  CAS  PubMed  Google Scholar 

  • Hegyi, L., Thway, K., Newton, R., Osin, P., Nerurkar, A., Hayes, A. J., & Fisher, C. (2009). Malignant myoepithelioma arising in adenomyoepithelioma of the breast and coincident multiple gastrointestinal stromal tumors in a patient with neurofibromatosis type 1. Journal of Clinical Pathology, 62(7), 653–655.

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  • Hungermann, D., Buerger, H., Oehlschlegel, C., Herbst, H., & Boecker, W. (2005). Adenomyoepithelial tumors and myoepithelial carcinomas of the breast – A spectrum of monophasic and biphasic tumors dominated by immature myoepithelial cells. BMC Cancer, 5, 92.

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  • Lee, S., Oh, S. Y., Kim, S.-H., et al. (2015). Malignant adenomyoepithelioma of the breast and responsiveness to eribulin. Journal of Breast Cancer, 18(4), 400–403.

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  • Nadelman, C. M., Leslie, K. O., & Fishbein, M. C. (2006). “Benign,” metastasizing adenomyoepithelioma of the breast: A report of 2 cases. Archives of Pathology & Laboratory Medicine, 130(9), 1349–1353.

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  • Petrozza, V., Pasciuti, G., Pacchiarotti, A., et al. (2013). Breast adenomyoepithelioma: A case report with malignant proliferation of epithelial and myoepithelial elements. World Journal of Surgical Oncology, 11, 285.

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  • Trojani, M., Guiu, M., Trouette, H., De Mascarel, I., & Cocquet, M. (1992). Malignant adenomyoepithelioma of the breast. An immunohistochemical, cytophotometric, and ultrastructural study of a case with lung metastases. American Journal of Clinical Pathology, 98(6), 598–602.

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  • Warrier, S., Hwang, S., Ghaly, M., & Matthews, A. (2013). Adenomyoepithelioma with ductal carcinoma in situ: A case report and review of the literature. Case Reports in Surgery, 2013, 521417.

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  • Yoon, J. Y., & Chitale, D. (2013). Adenomyoepithelioma of the breast: A brief diagnostic review. Archives of Pathology & Laboratory Medicine, 137(5), 725–729.

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Author information

Authors and Affiliations

  1. Pathology Department, BC Cancer Agency, University of British Columbia, Vancouver, BC, Canada

    Malcolm Hayes

Authors
  1. Malcolm Hayes
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Corresponding author

Correspondence to Malcolm Hayes .

Editor information

Editors and Affiliations

  1. Unit of Pathology, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Italy

    Anna Sapino

  2. Department of Medical Sciences, University of Turin, Turin, Italy

    Anna Sapino

  3. 2nd Department of Pathology, Semmelweis University, Budapest, Hungary

    Janina Kulka

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Hayes, M. (2020). Malignant Adenomyoepithelioma (M-AME). In: Sapino, A., Kulka, J. (eds) Breast Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-62539-3_4736

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  • DOI: https://doi.org/10.1007/978-3-319-62539-3_4736

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-62538-6

  • Online ISBN: 978-3-319-62539-3

  • eBook Packages: MedicineReference Module Medicine

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