Breast Pathology

2020 Edition
| Editors: Anna Sapino, Janina Kulka

Mammary Myofibroblastoma

  • Gaetano MagroEmail author
  • Lucia Salvatorelli
Reference work entry


Benign spindle cell tumor; Fibroma; Myogenic stromal tumor


Myofibroblastoma (MFB) is a relatively rare benign stromal tumor of the breast (Wargotz et al. 1987b; Magro et al. 2001, 2012a; Magro 2016), which belongs to the family of the “benign spindle cell tumors of the mammary stroma” (Magro et al. 2001, 2002a). These tumors are closely related lesions within a continuous morphological spectrum, variably composed of cells ranging from spindly fibroblastic-like cells to plump myofibroblasts (Magro et al. 2001, 2002a). As its name implies, MFB is composed of cells which show myofibroblastic differentiation at morphological, immunohistochemical, and ultrastructural level (Wargotz et al. 1987b; Magro et al. 2001, 2002a, 2016; Magro 2008). Other tumors, such as the benign fibroblastic spindle cell tumor, the spindle cell lipoma of the breast, and tumors with hybrid features, have a fibroblastic profile, with cells stained with vimentin and CD34 by means of...

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References and Further Reading

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Authors and Affiliations

  1. 1.Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Azienda Ospedaliero-Universitaria “Policlinico-Vittorio Emanuele,” Anatomic Pathology Section, School of MedicineUniversity of CataniaCataniaItaly