Breast Pathology

2020 Edition
| Editors: Anna Sapino, Janina Kulka

Apocrine Carcinoma

  • Semir VranicEmail author
  • Zoran Gatalica
Reference work entry


Carcinoma with apocrine differentiation; Invasive apocrine carcinoma


Carcinoma with apocrine differentiation (invasive apocrine carcinoma) is defined by “WHO Classification of Tumours of the Breast” as “any invasive carcinoma in which cells show the cytological features of apocrine cells” (O’Malley and Lakhani 2012). More strictly, it is a breast cancer characterized by apocrine morphology (abundant eosinophilic and granular cytoplasm, centrally/eccentrically located nuclei with prominent nucleoli and distinct cell borders) and a distinct steroid receptor profile: Estrogen receptor (ER)-negative and androgen receptor (AR)-positive cells (Vranic et al. 2013) (Fig. 1ac).
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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Pathology, Clinical Centre and School of MedicineUniversity of SarajevoSarajevoBosnia and Herzegovina
  2. 2.College of MedicineQatar UniversityDohaQatar
  3. 3.Caris Life SciencesPhoenixUSA