Neuroimaging in Normal Brain Aging

  • Meike W. VernooijEmail author
  • Frederik Barkhof
Living reference work entry


In the evaluation of age-related neurological diseases in clinical neuroradiology, knowledge on the background of “normal” brain aging and its associated changes is important but often overlooked. Radiological techniques applied to assess neurodegeneration will also show a variety brain changes that may be part of the “normal” aging spectrum, such as brain atrophy, white matter hyperintensities, silent brain infarcts, cerebral microbleeds, enlarged perivascular spaces, and iron accumulation. This chapter describes typical structural brain changes seen on imaging studies in “normal” aging and includes practical guidelines for application in daily clinical neuroradiology practice to identify abnormality.


Brain aging Atrophy White matter hyperintensities Infarcts Microbleeds Iron deposition 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Epidemiology, Department of Radiology and Nuclear MedicineErasmus MC University Medical CenterRotterdamThe Netherlands
  2. 2.Department of Radiology and Nuclear MedicineVU University Medical CenterAmsterdamThe Netherlands
  3. 3.Department of NeuroradiologyUniversity College London, Institute of NeurologyLondonUK

Section editors and affiliations

  • Sven Haller
    • 1
  1. 1.AffideaGenevaSwitzerland

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