Generic Name
Paliperidone
Brand Name
Invega, Invega Sustenna, Invega Trinza
Class
Antipsychotics, second generation, mood stabilizer
Proposed Mechanism(s) of Action
Combination of central dopamine D2 and serotonin 5-HT2A receptor antagonism
Indication
For the treatment of schizophrenia and manic or mixed bipolar 1 episodes
Off-Label Use
Agitation associated with a myriad of psychiatric conditions and dementia. Borderline personality disorder. Disruptive behavioral disorders associated with childhood.
Side Effects
Serious
Increased risk of mortality in elderly patients with dementia-related psychosis, mania. Extrapyramidal symptoms, prolongation of Q-T interval, agranulocytosis.
Common
Headache, dizziness, somnolence, dry mouth, nausea, tachycardia, diarrhea, orthostatic hypotension, weight gain.
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Additional Information
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Gonzalez, E.A. (2018). Paliperidone. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_9271
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DOI: https://doi.org/10.1007/978-3-319-57111-9_9271
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Online ISBN: 978-3-319-57111-9
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