Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_9270

Generic Name


Brand Name



Antidepressants, other

Proposed Mechanism(s) of Action

Enhancement of serotonergic activity in the CNS through inhibition of the reuptake of serotonin (5-HT). It also has several other activities including 5-HT3 receptor antagonism and 5-HT1A receptor agonism.


Major depressive disorder.

Off-Label Use

Neuropathic pain, chronic pain, generalized anxiety disorder, stress urinary incontinence, and fibromyalgia.

Side Effects


Seizures; hypomania; increased suicidal ideation, attempts, and completion; hyponatremia (SIAH).


Nausea, diarrhea, dry mouth, constipation, vomiting, abnormal dreams, dizziness, weight gain.

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com
  2. Free Drug Online and PDA Software. www.medscape.com
  3. Free Drug Online and PDA Software. www.medscapepsychiatry.com
  4. Jain, R., Mahableshwarkar, A. R., Jacobsen, P. L., Chen, Y., & Thase, M. E. (2013). A randomized, double-blind, placebo-controlled 6-wk trial of the efficacy and tolerability of 5 mg vortioxetine in adults with major depressive disorder. The International Journal of Neuropsychopharmacology, 16(2), 313–321.PubMedCrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  2. 2.Utah State UniversityLoganUSA