Generic Name
Valbenazine
Brand Name
Ingrezza
Class
Central Monoamine-Depleting Agents
Proposed Mechanism(s) of Action
Reversible inhibition of vesicular monoamine transporter 2 (VMAT2), which is a transporter that regulates monoamine uptake from the cytoplasm to the synaptic vesicle for storage and release from the presynaptic cell.
Indication
Treatment of tardive dyskinesia in adults.
Off Label Use
N/A
Side Effects
Serious
Akathisia, balance disorders/fall, prolonged QT syndrome, especially if co-administered with strong CYP2D6 or CYP3A4 inhibitors, or with patients who are poor CYP2D6 metabolizers.
Common
Anticholinergic effects, headache, vomiting, nausea, arthralgia, somnolence.
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References and Readings
Bari, M., Shiwach, R., Jimenez, R., Siegert, S., & O’Brien, C. (2016). Open-label extension of KINECT: A phase 2 study of Valbenazine (NBI-98854) for Tardive Dyskinesia (S27. 001). Neurology, 86(16 Supplement), S27–001.
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Hauser, R. A., Factor, S. A., Marder, S. R., Knesevich, M. A., Ramirez, P. M., Jimenez, R., …, O’Brien, C. F. (2017). KINECT 3: A phase 3 randomized, double-blind, placebo-controlled trial of valbenazine for tardive dyskinesia. American Journal of Psychiatry, 174(5), 476–484.
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Gonzalez, E.A. (2018). Valbenazine. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_9268
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DOI: https://doi.org/10.1007/978-3-319-57111-9_9268
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