Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Antidepressant Discontinuation Syndrome

  • Cynthia RolstonEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_9175


Antidepressant discontinuation symptoms; Antidepressant withdrawal syndrome (not preferred)


Antidepressant discontinuation syndrome (ADS) is cluster of physical and psychological symptoms that may arise after sudden discontinuation (either end of use or change in formulation) of antidepressant medication of any class, including tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), serotonin-specific reuptake inhibitors (SSRIs), SNRIs (serotonin norepinephrine reuptake inhibitors), and others (including noradrenergic and specific serotonergic antidepressant).


ADS is classified under medication-induced movement disorders in the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5; American Psychiatric Association 2013).

Current Knowledge

Clinical Presentation and Diagnosis

Consensus does not yet exist on diagnostic criteria for ADS. Symptoms begin abruptly (within days), continue only briefly even if untreated (24 h–3...

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References and Readings

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PM&RVirginia Commonwealth University-Medical College of VirginiaRichmondUSA