Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Macular Degeneration

  • Paige LysneEmail author
  • Yenisel Cruz-Almeida
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_9102

Definition

The leading cause of irreversible blindness in those over the age of 50 in the developed world, macular degeneration, is a progressive disease characterized by degeneration of the macula. The presence of drusen, generally pale or yellowish lesions found between the retinal pigment epithelium and Bruch’s membrane in the eye, is thought to be the first sign of age-related macular degeneration (AMD) (Khandhadia et al. 2012). Excess drusen can lead to damage of the retinal pigment epithelium which has several functions including cytokine secretion and nutrient transport. Early, intermediate, and advanced AMD are all classified, using a system created by the Age-Related Eye Disease Study, by the size of the drusen present/not present in the eye. Smaller and fewer drusen are more associated with early AMD and less visual impairment, whereas larger and more prevalent drusen are associated with advanced AMD and generally much more visual impairment. Advanced AMD is classified as...

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References

  1. Abdelsalam, A., Del Priore, L., & Zarbin, M. A. (1999). Drusen in age-related macular degeneration: Pathogenesis, natural course, and laser photocoagulation–induced regression. Survey of Ophthalmology, 44(1), 1–29.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Age-Related Eye Disease Study Research Group. (2000). Risk factors associated with age-related macular degeneration: A case-control study in the age-related eye disease study – Age-related eye disease study report number 3. Ophthalmology, 107(12), 2224–2232.CrossRefGoogle Scholar
  3. De Jong, P. T. (2006). Age-related macular degeneration. New England Journal of Medicine, 355(14), 1474–1485.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Jager, R. D., Mieler, W. F., & Miller, J. W. (2008). Age-related macular degeneration. New England Journal of Medicine, 358(24), 2606–2617.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Khandhadia, S., Cherry, J., & Lotery, A. J. (2012). Age-related macular degeneration. In Neurodegenerative diseases (pp. 15–36). New York: Springer.CrossRefGoogle Scholar
  6. Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J. Y., Sackler, R. S., Haynes, C., …, & Bracken, M. B. (2005). Complement factor H polymorphism in age-related macular degeneration. Science, 308(5720), 385–389.CrossRefPubMedPubMedCentralGoogle Scholar
  7. Lim, L. S., Mitchell, P., Seddon, J. M., Holz, F. G., & Wong, T. Y. (2012). Age-related macular degeneration. The Lancet, 379(9827), 1728–1738.CrossRefGoogle Scholar
  8. Rosenfeld, P. J., Brown, D. M., Heier, J. S., Boyer, D. S., Kaiser, P. K., Chung, C. Y., & Kim, R. Y. (2006). Ranibizumab for neovascular age-related macular degeneration. New England Journal of Medicine, 355(14), 1419–1431.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Schmidt-Erfurth, U., & Hasan, T. (2000). Mechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degeneration. Survey of Ophthalmology, 45(3), 195–214.CrossRefPubMedPubMedCentralGoogle Scholar
  10. Seddon, J. M., Ajani, U. A., Sperduto, R. D., Hiller, R., Blair, N., Burton, T. C., …, & Yannuzzi, L. A. (1994). Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. JAMA, 272(18), 1413–1420.Google Scholar

Copyright information

© Springer International Publishing AG (outside the USA) 2018

Authors and Affiliations

  1. 1.Department of Aging and Geriatric Research, Institute of AgingUniversity of Florida – College of MedicineGainesvilleUSA
  2. 2.Pain Research and Intervention Center of Excellence Clinical and Translational Science InstituteUniversity of FloridaGainesvilleUSA