Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Diffusion Kurtosis Mapping

  • Matilde IngleseEmail author
  • Maria Petracca
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_9079

Synonyms

Diffusion kurtosis imaging; Diffusion kurtosis mapping; Diffusion tensor imaging; Diffusion weighted imaging; DKI; DKM; DTI; DWI; Fibre bundle orientation; Gaussian; Ischemia; Water diffusion; White matter hyperintensities; White matter tracts; WMH

Definition

In biological tissues, the presence of barriers (e.g., cell membranes) alters the water diffusion so that the actual diffusion diverges from the theoretical Gaussian distribution expected in a homogeneous system (i.e., a glass of water). Diffusional kurtosis imaging (DKI) is a diffusion-weighted MRI method which measures both Gaussian and non-Gaussian properties of water diffusion (Jensen et al. 2005). As such, it allows the characterization of diffuse microscopic injury in both anisotropic and isotropic systems (i.e., white matter tracts and grey matter) (Raz et al. 2013; Fieremans et al. 2011). In comparison with other diffusion imaging techniques, DKI shows a higher accuracy in the estimation of fiber bundle...

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References and Readings

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurologyRadiology and Neuroscience, Icahn School of Medicine at Mount SinaiNew YorkUSA
  2. 2.Department of NeurologyIcahn School of Medicine at Mount SinaiNew YorkUSA