Resting-State Functional Connectivity MRI (fcMRI)
Functional connectivity; Intrinsic functional connectivity; Resting-state connectivity; Resting-state fMRI; Resting-state functional connectivity MRI (fcMRI)
A method for evaluating the temporal synchronization or correlation between brain regions when a participant passively lies awake in a brain imaging scanner.
In the early 1990s, functional magnetic resonance imaging (fMRI) using blood oxygenation level-dependent (BOLD) contrast was invented (Belliveau et al. 1991; Ogawa et al. 1990). The technology exploited inherent differences in the magnetic properties of oxygenated and deoxygenated hemoglobin to provide clinicians and scientists the opportunity to measure brain activity in awake behaving humans endogenously – without the use of chemicals or radiation. A standard fMRI experimental design consists of brief periods of time (e.g., blocks of 20 sec) during which a participant is asked to either perform a behavioral task of interest or a...
References and Readings
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