Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Resting-State Functional Connectivity MRI (fcMRI)

  • Jared A. NielsenEmail author
  • R. Matthew Hutchison
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_9077


Functional connectivity; Intrinsic functional connectivity; Resting-state connectivity; Resting-state fMRI; Resting-state functional connectivity MRI (fcMRI)


A method for evaluating the temporal synchronization or correlation between brain regions when a participant passively lies awake in a brain imaging scanner.

Historical Background

In the early 1990s, functional magnetic resonance imaging (fMRI) using blood oxygenation level-dependent (BOLD) contrast was invented (Belliveau et al. 1991; Ogawa et al. 1990). The technology exploited inherent differences in the magnetic properties of oxygenated and deoxygenated hemoglobin to provide clinicians and scientists the opportunity to measure brain activity in awake behaving humans endogenously – without the use of chemicals or radiation. A standard fMRI experimental design consists of brief periods of time (e.g., blocks of 20 sec) during which a participant is asked to either perform a behavioral task of interest or a...

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Departments of Psychiatry and PsychologyHarvard University and Massachusetts General HospitalCambridgeUSA
  2. 2.Biogen Inc.CambridgeUSA