Skip to main content
SpringerLink
Log in

Chemo Brain

  • Reference work entry
  • First Online:
Book cover Encyclopedia of Clinical Neuropsychology

  • 15 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 899.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 1,099.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ahles, T. A., Root, J. C., & Ryan, E. L. (2012). Cancer- and cancer treatment-associated cognitive change: An update on the state of the science. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 30(30), 3675–3686. https://doi.org/10.1200/JCO.2012.43.0116.

    Article  PubMed  PubMed Central  Google Scholar 

  • Aluise, C. D., Sultana, R., Tangpong, J., Vore, M., St Clair, D., Moscow, J. A., & Butterfield, D. A. (2010). Chemo brain (chemo fog) as a potential side effect of doxorubicin administration: Role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction. Advances in Experimental Medicine and Biology, 678, 147–156.

    Article  PubMed  Google Scholar 

  • Askren, M. K., Jung, M., Berman, M. G., Zhang, M., Therrien, B., Peltier, S., et al. (2014). Neuromarkers of fatigue and cognitive complaints following chemotherapy for breast cancer: A prospective fMRI investigation. Breast Cancer Research and Treatment, 147(2), 445–455. https://doi.org/10.1007/s10549-014-3092-6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dietrich, J., Han, R., Yang, Y., Mayer-Pröschel, M., & Noble, M. (2006). CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. Journal of Biology, 5(7), 22. https://doi.org/10.1186/jbiol50.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ferguson, R. J., Ahles, T. A., Saykin, A. J., McDonald, B. C., Furstenberg, C. T., Cole, B. F., & Mott, L. A. (2007). Cognitive-behavioral management of chemotherapy-related cognitive change. Psycho-Oncology, 16(8), 772–777. https://doi.org/10.1002/pon.1133.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ganz, P. A., Kwan, L., Castellon, S. A., Oppenheim, A., Bower, J. E., Silverman, D. H. S., et al. (2013). Cognitive complaints after breast cancer treatments: Examining the relationship with neuropsychological test performance. JNCI Journal of the National Cancer Institute, 105(11), 791–801. https://doi.org/10.1093/jnci/djt073.

    Article  PubMed  PubMed Central  Google Scholar 

  • Han, R., Yang, Y. M., Dietrich, J., Luebke, A., Mayer-Pröschel, M., & Noble, M. (2008). Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system. Journal of Biology, 7(4), 12. https://doi.org/10.1186/jbiol69.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hede, K. (2008). Chemobrain is real but may need new name. JNCI Journal of the National Cancer Institute, 100(3), 162–169. https://doi.org/10.1093/jnci/djn007.

    Article  PubMed  Google Scholar 

  • Inagaki, M., Yoshikawa, E., Matsuoka, Y., Sugawara, Y., Nakano, T., Akechi, T., et al. (2007). Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy. Cancer, 109(1), 146–156. https://doi.org/10.1002/cncr.22368.

    Article  PubMed  Google Scholar 

  • Joshi, G., Hardas, S., Sultana, R., St Clair, D. K., Vore, M., & Butterfield, D. A. (2007). Glutathione elevation by gamma-glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain. Journal of Neuroscience Research, 85(3), 497–503. https://doi.org/10.1002/jnr.21158.

    Article  PubMed  Google Scholar 

  • Kohli, S., Fisher, S. G., Tra, Y. (2007). The cognitive effects of modafinil in breast cancer survivors: A randomized clinical trial. ASCO Annual Cancer, 115, 2605–16.

    Google Scholar 

  • Matsuda, T., Takayama, T., Tashiro, M., Nakamura, Y., Ohashi, Y., & Shimozuma, K. (2005). Mild cognitive impairment after adjuvant chemotherapy in breast cancer patients – evaluation of appropriate research design and methodology to measure symptoms. Breast Cancer (Tokyo, Japan), 12(4), 279–287.

    Article  Google Scholar 

  • McDougall, G. J., Oliver, J. S., & Scogin, F. (2014). Memory and cancer: A review of the literature. Archives of Psychiatric Nursing, 28(3), 180–186. https://doi.org/10.1016/j.apnu.2013.12.005.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mustafa, S., Walker, A., & Bennett, G. (2008). 5-fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus. European Journal of Neuroscience, 28, 323–330.

    Article  PubMed  Google Scholar 

  • Myers, J. S., Pierce, J., & Pazdernik, T. (2008). Neurotoxicology of chemotherapy in relation to cytokine release, the blood-brain barrier, and cognitive impairment. Oncology Nursing Forum, 35, 916–920.

    Article  PubMed  Google Scholar 

  • Nelson, C. J., Nandy, N., & Roth, A. J. (2007). Chemotherapy and cognitive deficits: Mechanisms, findings, and potential interventions. Palliative & Supportive Care, 5, 273–280.

    Article  Google Scholar 

  • Peralta, E. A. (2013). Neuropsychological sequelae of breast cancer and its treatment. In C. A. Noggle & R. S. Dean (Eds.), The neuropsychology of cancer and oncology. New York: Springer Publishing Co.

    Google Scholar 

  • Pomykala, K. L., de Ruiter, M. B., Deprez, S., McDonald, B. C., & Silverman, D. H. S. (2013). Integrating imaging findings in evaluating the post-chemotherapy brain. Brain Imaging and Behavior, 7(4), 436–452. https://doi.org/10.1007/s11682-013-9239-y.

    Article  PubMed  Google Scholar 

  • Scherling, C. S., & Smith, A. (2013). Opening up the window into “chemobrain”: A neuroimaging review. Sensors (Basel, Switzerland), 13(3), 3169–3203. https://doi.org/10.3390/s130303169.

    Article  PubMed  PubMed Central  Google Scholar 

  • Seigers, R., Schagen, S. B., Beerling, W., Boogerd, W., van Tellingen, O., van Dam, F. S. A. M., et al. (2008). Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat. Behavioural Brain Research, 186(2), 168–175. https://doi.org/10.1016/j.bbr.2007.08.004.

    Article  PubMed  Google Scholar 

  • Silverman, D. H. S., Dy, C. J., Castellon, S. A., Lai, J., Pio, B. S., Abraham, L., et al. (2007). Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5–10 years after chemotherapy. Breast Cancer Research and Treatment, 103(3), 303–311. https://doi.org/10.1007/s10549-006-9380-z.

    Article  PubMed  Google Scholar 

  • Taillibert, S., & Voillery, D. (2007). Chemobrain: Is systemic chemotherapy neurotoxic? Current Opinion in Oncology, 19, 623–627.

    Article  PubMed  Google Scholar 

  • Tannock, I. F., Ahles, T. A., Ganz, P. A., & Van Dam, F. S. (2004). Cognitive impairment associated with chemotherapy for cancer: Report of a workshop. Journal of Clinical Oncology, 22, 2233–2239. Presented at the Journal of Clinical Oncology : official journal of the American Society of Clinical Oncology. https://doi.org/10.1200/JCO.2004.08.094.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland

    Samantha Knight

  2. Department of Psychology, Drexel University, Philadelphia, PA, USA

    Daniel Smith

  3. Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Daniel Smith

  4. Child and Adolescent Psychiatry and Behavioral Sciences, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Carol L. Armstrong

Authors
  1. Samantha Knight
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Daniel Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carol L. Armstrong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Samantha Knight .

Editor information

Editors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA

    Jeffrey S. Kreutzer

  2. Kessler Foundation, Pleasant Valley Way, West Orange, NJ, USA

    John DeLuca

  3. Independent Practice, Wynnewood, PA, USA

    Bruce Caplan

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Knight, S., Smith, D., Armstrong, C.L. (2018). Chemo Brain. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_9027

Download citation

Publish with us

Policies and ethics

Search

Navigation