Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Acute Myelogenous Leukemia

  • Jacqueline L. CunninghamEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_86


Acute myeloid leukemia; AML


Acute myelogenous leukemia (AML) is a form of cancer of the white blood cells (leukocytes). It is a relatively rare cancer that occurs more commonly in adults than in children, with more men affected than women. The median age at diagnosis is 63 years.

Current Knowledge


Acute forms of leukemia are characterized by the rapid proliferation of immature blood cells which rapidly crowd out mature, functional cells. In AML, the cell type is granuloid, whose cancerous change disrupts its normal ability to form red cells, some types of white cells, and platelets. Resulting symptoms are anemia, easy bruising and bleeding, and disruption to the body’s ability to resist infection. Impaired cognition and fatigue are also strongly associated with AML. Whereas impairments in these areas have been attributed to effects of chemotherapy, recent research by Meyers, Albitar, and Estey (2005) has identified differing cytokine levels present prior...

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References and Readings

  1. Meyers, C. A., Albitar, M., & Estey, E. (2005). Cognitive impairment, fatigue, and cytokine levels in patients with acute myelogenous leukemia or myelodysplastic syndrome. Cancer, 104, 788–793.PubMedCrossRefGoogle Scholar
  2. Pui, C.-H. (2003). Treatment of acute leukemias: New directions for clinical research. New York: Humana Press.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PsychologyChildren’s Hospital of PhiladelphiaPhiladelphiaUSA