Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Protopathic Pain

  • Kerry DonnellyEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_777


A variant of nociceptive pain (pain resulting from ongoing activation of primary afferent neurons by noxious stimuli), protopathic pain is transmitted by C fibers to the spinal cord. C-fibers are unmyelinated, small-diameter, and slow-conducting, resulting in poorly localized, dull, aching pain. The fibers are sensitive to mechanical, thermal, and chemical stimuli, resulting in diffuse pain which is particularly sensitive to opioid therapy.


References and Readings

  1. McCaffery, M., & Pasero, C. (1999). Pain clinical manual (2nd ed.). St. Louis: Mosby.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.VA WNY Healthcare SystemUniversity of Buffalo (SUNY) Behavioral Health Careline (116B)BuffaloUSA