Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • Bruce J. DiamondEmail author
  • Emily Desbiens
  • Rebecca Pavlick
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_542


Chelation; Chelation therapy; EDTA therapy

Short Description or Definition

Chelation therapy has applications in allopathic medicine, and the technique has also been embraced by practitioners of complementary, alternative, and integrative medicine (CAIM). While CAIM practitioners have used this technique to treat cardiovascular disease, allopathic practitioners consider chelation therapy to be highly effective and is the treatment of choice in treating heavy metal poisoning (Ernst et al. 2001) although more recent work suggests that chelation plus antioxidant supplementation to be more effective than monotherapeutic interventions (Flora et al. 2008). Recent clinical applications have included autism spectrum disorder (ASD) (James et al. 2015; Rossignol 2009), although more extensive research is needed. Some research also suggests that iron chelation therapy with desferrioxamine may have application in the treatment of malaria (Mabeza et al. 1999).



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Further Reading

  1. Ernst, E., Pittler, M. H., Stevinson, C., White, A., & Eisenberg, D. (Eds.). (2001). The desktop guide to complementary and alternative medicine: An evidence based approach. Amsterdam: Elsevier Health Sciences.Google Scholar
  2. Flora, S. J. S., Mittal, M., & Mehta, A. (2008). Heavy metal induced oxidative stress & its possible reversal by chelation therapy. Indian Journal of Medical Research, 128(4), 501–523.PubMedGoogle Scholar
  3. James, S., Stevenson, S. W., Silove, N., & Williams, K. (2015). Chelation for autism spectrum disorder (ASD). Cochrane Database Syst Reviews, 5, CD010766.Google Scholar
  4. Kontoghiorghes, G. J. (1995). New concepts of iron and aluminum chelation therapy with oral L1 (deferiprone) and other chelators: A review. Analyst, 120, 845–851.PubMedCrossRefGoogle Scholar
  5. Mabeza, G. F., Loyevsky, M., Gordeuk, V. R., & Weiss, G. (1999). Iron chelation therapy for malaria: A review. Pharmacology & Therapeutics, 81, 53–75.CrossRefGoogle Scholar
  6. Rossignol, D. A. (2009). Novel and emerging treatments for autism spectrum disorders: A systematic review. Annals of Clinical Psychiatry., 21(4), 213–236.PubMedGoogle Scholar
  7. Seely, D. M., Wu, P., & Mills, E. J. (2005). EDTA chelation therapy for cardiovascular disease: A systematic review. BMC Cardiovascular Disorders, 5, 32–38.PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Bruce J. Diamond
    • 1
    Email author
  • Emily Desbiens
    • 1
  • Rebecca Pavlick
    • 1
  1. 1.Department of PsychologyWilliam Paterson UniversityWayneUSA