Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • Jennifer C. G. LarsonEmail author
  • Yana Suchy
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_526


Astrocytosis; Glioses


Gliosis refers to proliferation of glial cells, either by hypertrophy (increased cell size) or hyperplasia (increased cellular division), in response to a CNS insult. For example, gliosis may occur in order to encapsulate a brain tumor or to provide scaffolding to support healthy tissue surrounding areas of insult or lesion. In many cases, gliosis leads to scarring within the CNS. Depending on the type of insult, gliosis can affect different glial cell subpopulations, primarily astrocytes and microglia and to a lesser extent oligodendrocytes. Gliosis is one of the principal histopathological indicators of brain damage.


References and Readings

  1. Croisier, E., & Graeber, M. (2006). Glial degeneration and reactive gliosis in alpha-synucleinopathies: The emerging concept of primary gliodegeneration. Acta Neruopathologica, 112, 517–530.CrossRefGoogle Scholar
  2. Kumar, V., Fausto, N., & Abbas, A. (2004). Robbins & Cotran pathologic basis of disease (7th ed.). Philadelphia: Saunders.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Physical Medicine and RehabilitationUniversity of MichiganAnn ArborUSA
  2. 2.Department of PsychologyThe University of UtahSalt Lake CityUSA