Behavioral variant frontotemporal dementia; Dementia of frontal lobe type; Frontal lobe dementia
Short Description or Definition
The term “Pick’s disease” has been used to describe a neuropathological entity and/or a clinical syndrome. Pathologists use this term on the basis of the histologic criteria of argyrophilic inclusions (Pick bodies) and ballooned neurons (Pick cells). As a clinical syndrome, Pick’s disease is used to describe progressive alterations in personality and behavior (e.g., frontotemporal dementia [FTD]), and/or language (e.g., progressive aphasia).
Developments in molecular pathology have led to the classification of Pick’s disease as a tauopathy, defined neuropathologically by the presence of tau immunoreactive Pick bodies (Lee et al. 2001). Compared to other tauopathies (e.g., progressive supranuclear palsy [PSP] and corticobasal degeneration [CBD]), the distribution of pathology is more likely to be cortical than subcortical, and Pick...
References and Readings
- Noble, W., Planel, E., Zehr, C., Olm, V., Meyerson, J., Suleman, F., et al. (2005). Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proceedings of the National Academy of Sciences of the United States of America, 102(19), 6990–6995.PubMedCentralCrossRefPubMedGoogle Scholar
- Pick, A. (1892). Über die Beziehungen der senilen Hirnatrophie zur Aphasie. Prager Med Wochenschr, 17, 165–167.Google Scholar