Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Lewy Bodies

  • Matthew Kraybill
  • Yana Suchy
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_503


Alpha-synuclein inclusions


Lewy bodies (LBs) are an abnormal aggregation of protein that develops inside the cytoplasm of neuronal cells. LBs contain ubiquitin, alpha-synuclein, and other associated enzymes (see section “ Cell Biology” below for more detail) (McKeith 2000). LBs can vary in size from 8 μm to 30 μm in diameter. There may be a single LB or multiple LBs in a particular neuron (Masterman and Swanberg 2003). They are identified microscopically using histologic staining techniques and typically appear as spherical masses that have a dense core with a surrounding halo (see Fig. 1).
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References and Readings

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Matthew Kraybill
    • 1
  • Yana Suchy
    • 2
  1. 1.NeuropsychologyCottage Rehabilitation HospitalSanta BarbaraUSA
  2. 2.Department of PsychologyThe University of UtahSalt Lake CityUSA