Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Dementia with Lewy Bodies

  • Matthew Kraybill
  • Yana Suchy
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_502

Synonyms

Cortical Lewy body disease (CLBD); Diffuse Lewy body disease (DLBD); Lewy body dementia (LBD); Senile dementia of Lewy type

Definition

Dementia with Lewy bodies (DLB) is part of a spectrum of neurodegenerative disorders associated with dysregulation and aggregation of alpha-synuclein (McKeith 2006). DLB is characterized by progressive cognitive decline combined with three additional defining features: (1) pronounced fluctuations in alertness and attention (e.g., frequent drowsiness, lethargy, and disorganized speech), (2) visual hallucinations, and (3) parkinsonian motor symptoms (e.g., resting tremor, muscle rigidity, bradykinesia, and/or postural instability) (see Table 1; McKeith et al. 1996, 2005).
Dementia with Lewy Bodies, Table 1

Revised criteria for the clinical diagnosis of probable or possible DLB (Adapted from McKeith et al. (2005))

 

Central features

Core features

Suggestive features

Supportive features

Cognitive

Progressive dementia with impairments in (a) memory,...

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References and Readings

  1. Aarsland, D., Ballard, C., Rongve, A., Broadstock, M., & Svenningsson, P. (2012). Clinical trials of dementia with Lewy bodies and Parkinson’s disease dementia. Current Neurology and Neuroscience Reports, 12(5), 492–501.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Ballard, C. G., Jacoby, R., Del Ser, T., Khan, M. N., Munoz, D. G., Holmes, C., Nagy, Z., Perry, E. K., Joachim, C., Jaros, E. & O’Brien, J. T. (2004). Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with Lewy bodies. American Journal of Psychiatry, 161(5), 843–849.PubMedCrossRefPubMedCentralGoogle Scholar
  3. Cagnin, A., Gnoato, F., Jelcic, N., Favaretto, S., Zarantonello, G., Ermani, M., & Dam, M. (2013). Clinical and cognitive correlates of visual hallucinations in dementia with Lewy bodies. Journal of Neurology, Neurosurgery & Psychiatry, 84(5), 505–510.CrossRefGoogle Scholar
  4. Goldmann Gross, R., Siderowf, A., & Hurtig, H. I. (2008). Cognitive impairment in Parkinson’s disease and dementia with Lewy bodies: A spectrum of disease. Neurosignals, 16(1), 24–34.CrossRefGoogle Scholar
  5. Lennox, G., & Lowe, J. (1996). The clinical diagnosis and misdiagnosis of Lewy body dementia. In R. Perry, I. McKeith, & E. Perry (Eds.), Dementia with Lewy bodies: Clinical, pathological, and treatment issues (pp. 9–20). Cambridge: Cambridge University Press.CrossRefGoogle Scholar
  6. Levy, J. A., & Chelune, G. J. (2007). Cognitive-behavioral profiles of neurodegenerative dementias: Beyond Alzheimer’s disease. Journal of Geriatric Psychiatry and Neurology, 20(4), 227–238.PubMedCrossRefPubMedCentralGoogle Scholar
  7. Mayo, M. C., & Bordelon, Y. (2014). Dementia with Lewy bodies. Seminars in Neurology, 34(2), 182–188.PubMedCrossRefPubMedCentralGoogle Scholar
  8. McKeith, I. G. (2006). Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the Consortium on DLB International Workshop. Journal of Alzheimer’s Disease, 9(3 Suppl), 417–423.PubMedCrossRefPubMedCentralGoogle Scholar
  9. McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., et al. (1996). Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the Consortium on DLB International Workshop. Neurology, 47(5), 1113–1124.CrossRefGoogle Scholar
  10. McKeith, I. G., Perry, E. K., & Perry, R. H. (1999). Report of the second dementia with Lewy body international workshop: Diagnosis and treatment. Consortium on Dementia with Lewy Bodies. Neurology, 53(5), 902–905.PubMedCrossRefPubMedCentralGoogle Scholar
  11. McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O’Brien, J. T., Feldman, H., et al. (2005). Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium. Neurology, 65(12), 1863–1872.CrossRefGoogle Scholar
  12. McLaughlin, N. C. R., Chang, A. C., & Malloy, P. (2012). Verbal and nonverbal learning and recall in dementia with Lewy bodies and Alzheimer’s disease. Applied Neuropsychology: Adult, 19(2), 86–89.CrossRefGoogle Scholar
  13. Simnard, M., Van Reekum, R., & Cohen, T. (2000). A review of the cognitive and behavioral symptoms in dementia with Lewy bodies. Journal of Neuropsychiatry and Clinical Neurosciences, 12(4), 425–450.CrossRefGoogle Scholar
  14. Stinton, C., McKeith, I., Taylor, J. P., Lafortune, L., Mioshi, E., Mak, E., Cambridge, V., Mason, J., Thomas, A., & O’Brien, J. T. (2015). Pharmacological management of Lewy body dementia: A systematic review and meta-analysis. American Journal of Psychiatry, 172(8), 731–742.PubMedCrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Matthew Kraybill
    • 1
  • Yana Suchy
    • 2
  1. 1.NeuropsychologyCottage Rehabilitation HospitalSanta BarbaraUSA
  2. 2.Department of PsychologyUniversity of UtahSalt Lake CityUSA