Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Clinical Significance

  • Monica KuryloEmail author
  • Kimberly Fleming
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_2022

Clinical significance is a perceived, valued, and functionally relevant discrepancy in symptoms/abilities that reflects an important change in functioning. This can involve either an improvement (usually as a result of treatment or intervention) or a decline (typically due progression of illness or disorder) as measured by symptoms or impairment level.

Clinical significance also refers to a static condition of import – for example, a functionally relevant discrepancy between cognitive abilities in different domains (e.g., language vs. visual-perceptual abilities).

While clinical significance may be supported by statistically significant differences on quantitative measures of functioning, statistical significance cannot be equated with clinical significance.


References and Readings

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Departments of Psychiatry and Rehabilitation MedicineUniversity of Kansas Medical CenterKansas CityUSA
  2. 2.Department of Psychiatry and Behavioral SciencesThe University of Kansas KU Medical CenterKansas CityUSA