Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Mesial Frontal System

  • Denise KrchEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1901


Anterior cingulate system


The mesial frontal system originates in Brodmann’s area 24 and projects to the limbic striatum (i.e., ventromedial caudate, ventral putamen, nucleus accumbens, and olfactory tubercle). The ventral striatum also receives limbic input from the hippocampus, amygdala, and entorhinal cortices. Projections leaving these areas innervate the rostromedial globus pallidus interna, ventral pallidum, and rostrodorsal substantia nigra pars reticulata. From here, the pathway continues to the medial dorsal thalamic nucleus and then back to anterior cingulate cortex. Proximal and distal branches of the anterior cerebral artery and proximal branches of the posterior cerebral artery supply this system.

Current Knowledge

The mesial frontal system plays a role in motivated behavior and speech and motor initiation. Damage to any part of this system may result in a mesial frontal syndrome, which is characterized by reduced spontaneous activity that can range...

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References and Readings

  1. Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9, 357–381.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Miller, B. L., & Cummings, J. L. (Eds.). (1999). The human frontal lobes: Functions and disorders. New York: Guilford Press.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Kessler FoundationEast HanoverUSA