Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Multiple Sclerosis Quality of Life-54 Questionnaire

  • Tamara BushnikEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1821




Multiple Sclerosis Quality of Life-54 (MSQOL-54) is considered to be the most known disease-specific instrument for the evaluation of quality of life in patients with multiple sclerosis (MS). It was developed to combine generic quality of life aspects of the SF-36 with MS-targeted dimensions and ratings for the overall quality of life (Vickrey et al. 1995). Therefore, 18 disease-specific items were added to the original 36 items of the SF-36. The added MS-specific domains are health distress (4 items), sexual function (4 items), satisfaction with sexual function (1 item), overall quality of life (2 items), cognitive function (4 items), energy (1 item), pain (1 item), and social function (1 item). The 54 items are divided into 12 multi-item and 2 single-item scales. The MSQOL-54 items are transformed linearly to 0–100 scores, and final scores are obtained by averaging items within the scales. Exploratory factor analysis confirmed two dimensions:...

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References and Readings

  1. Rosato, R., Testa, S., Bertolotto, A., Confalonieri, P., Patti, F., Lugaresi, A., Grasso, M. G., Toscano, A., Giordano, A., & Solari, A. (2016). Development of a short version of MSQOL-54 using factor analysis and item response theory. PloS One, 11, e0153466. Epub ahead of print.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Vickrey, B. G., Hays, R. D., Harooni, R., Myers, L. W., & Ellison, G. W. (1995). A health-related quality of life measure for multiple sclerosis. Quality of Life Research, 4, 187–206.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Inter-Hospital Research and Knowledge TranslationRusk RehabilitationNew YorkUSA