Antidepressants are a class of medications that are used primarily in the treatment of clinically severe mood and anxiety disorders. The majority of effective antidepressants currently in use enhance neurotransmission of serotonin and/or norepinephrine. Generally, this is achieved by blocking the reuptake of the neurotransmitter substance(s), inhibiting the enzymes responsible for its metabolism, or directly stimulating the postsynaptic receptors (Iversen et al. 2009). Several antidepressants are also used in treating generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder (Bourin and Lambert 2002). Other conditions for which antidepressants have demonstrated efficacy include eating disorders (Powers and Bruty 2009), neuropathic pain (O’Connor and Dworkin 2009), stress incontinence, nocturnal enuresis, ejaculatory disorders (Michel et al. 2006), migraine headaches, fibromyalgia (Stone et al. 2003), attention deficit hyperactivity disorder (Chung et...
References and Readings
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