Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Anxiolytics

  • Chava CrequeEmail author
  • Stephanie A. Kolakowsky-Hayner
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1757

Synonyms

Anti-anxiety drugs; Anti-anxiety medications

Definition

Anxiolytics are prescription drugs used to reduce the severity and extent of symptoms due to anxiety-related disorders. The most commonly prescribed anxiolytic drugs are benzodiazepines, drugs used to treat generalized anxiety disorder, panic attacks, phobias, and other ongoing issues of excessive fear and dread. Medical illness often associated with high levels of anxiety also includes brain injury, heart disease, and COPD. There are six approved benzodiazepines in the USA today including the popular diazepam (Valium), lorazepam (Ativan), and alprazolam (Xanax). Anxiolytics are designed to impact neurotransmitters in the amygdala by increasing gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that diminishes the fear response. Other drugs with anxiolytic effects include selective serotonin reuptake inhibitors (SSRIs).

Neuropsychologists must be aware of the potential effects of anxiolytics on the physical,...

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References and Readings

  1. Cosci, F., Schruers, K., Faravelli, C., & Griez, E. (2004). The influence of alcohol oral intake on the effects of 35% CO2 challenge: A study in healthy volunteers. Acta Neuropsychiatrica, 16(2), 107–109.PubMedCrossRefGoogle Scholar
  2. Deacon, R., Bannerman, D., & Rawlins, J. (2002). Anxiolytic effects of cytotoxic hippocampal lesions in rats. Behavioral Neuroscience, 116(3), 494–497.PubMedCrossRefGoogle Scholar
  3. Harmer, C. J. (2012). Have no fear: The neural basis of anxiolytic drug action in generalized social phobia. Biological Psychiatry Journal, 73(4), 300–301.CrossRefGoogle Scholar
  4. Karl, T., Duffy, L., Scimone, A., Harvey, R., & Schofield, P. (2007). Altered motor activity, exploration and anxiety in heterozygous neuregulin 1 mutant mice: Implications for understanding schizophrenia. Genes, Brain, and Behavior, 6(7), 677–687.PubMedCrossRefGoogle Scholar
  5. Lanctôt, K., Herrmann, N., Mazzotta, P., Khan, L., & Ingber, N. (2004). GABAergic function in Alzheimer’s disease: Evidence for dysfunction and potential as a therapeutic target for the treatment of behavioural and psychological symptoms of dementia. Canadian Journal of Psychiatry, 49(7), 439–453.PubMedCrossRefGoogle Scholar
  6. McHugh, S., Deacon, R., Rawlins, J., & Bannerman, D. (2004). Amygdala and ventral hippocampus contribute differentially to mechanisms of fear and anxiety. Behavioral Neuroscience, 118(1), 63–78.PubMedCrossRefGoogle Scholar
  7. Stein, R. A., & Strickland, T. L. (1998). A review of the neuropsychological effects of commonly used prescription medications. Archives of Clinical Neuropsychology, 13(3), 259–284.PubMedCrossRefGoogle Scholar
  8. Treit, D., & Menard, J. (1997). Dissociations among the anxiolytic effects of septal, hippocampal, and amygdaloid lesions. Behavioral Neuroscience, 111(3), 653–658.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Psychology and NeuroscienceUniversity of Colorado BoulderBoulderUSA
  2. 2.Department of Rehabilitation MedicineIcahn School of Medicine at Mount SinaiNew YorkUSA