Drug resistance; Drug tolerance; Physiological tolerance
A physiological process central to drug addiction, the attenuation of or reduced response to a drug after prolonged exposure, or the ability to endure large doses of a drug. Drug tolerance increases the need for more and more drug to obtain the desired effect. While common in illicit drug use, clinicians should be aware of the potential in prescription medication as well. Prolonged use of the same prescription medication could result in physiological tolerance diminishing the intended outcome, for example, pain management. Negative or diminished results could impact mood, behavior, cognitive functioning, etc.
References and Readings
- Cheung, T., Bezzina, G., Body, S., Fone, K., Bradshaw, C., & Szabadi, E. (2007). Tolerance to the effect of 2,5-dimethoxy-4-iodoamphetamine (DOI) on free-operant timing behaviour: Interaction between behavioural and pharmacological mechanisms. Psychopharmacology, 192(4), 521–535.CrossRefPubMedPubMedCentralGoogle Scholar