Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • Stephanie A. Kolakowsky-HaynerEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1754


Drug resistance; Drug tolerance; Physiological tolerance


A physiological process central to drug addiction, the attenuation of or reduced response to a drug after prolonged exposure, or the ability to endure large doses of a drug. Drug tolerance increases the need for more and more drug to obtain the desired effect. While common in illicit drug use, clinicians should be aware of the potential in prescription medication as well. Prolonged use of the same prescription medication could result in physiological tolerance diminishing the intended outcome, for example, pain management. Negative or diminished results could impact mood, behavior, cognitive functioning, etc.


References and Readings

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Rehabilitation Medicine Icahn School of Medicine at Mount SinaiNew YorkUSA