Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Reuptake

  • Chava CrequeEmail author
  • Stephanie A. Kolakowsky-Hayner
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1749

Synonyms

Re-uptake; Reabsorption

Definition

Reuptake is the reabsorption of a secreted substance by the same cell that originally secreted it. It is essential in regulating the level of neurotransmitter in the synapse and therefore controls the time during which the substance is available for synaptic transmission. When a nerve releases a neurotransmitter, the neurotransmitter either travels to a receptor of a nearby cell or, in the case of reuptake, reattaches to the receptor of the cell that produced it. In this case, the neurotransmitter is taken back into the cell and recycled. The efficiency of the reuptake mechanism is often used to treat and regulate many psychological conditions that involve neurotransmitters, including depression and anxiety.

Cross-References

References and Readings

  1. Bowen, D., Procter, A., Mann, D., Snowden, J., Esiri, M., Neary, D., et al. (2008). Imbalance of a serotonergic system in frontotemporal dementia: Implication for pharmacotherapy. Psychopharmacology, 196(4), 603–610.PubMedCrossRefPubMedCentralGoogle Scholar
  2. Stein, M., Pollack, M., Bystritsky, A., Kelsey, J., & Mangano, R. (2005). Efficacy of low and higher dose extended-release venlafaxine in generalized social anxiety disorder: A 6-month randomized controlled trial. Psychopharmacology, 177(3), 280–288.PubMedCrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Psychology and NeuroscienceUniversity of Colorado BoulderBoulderUSA
  2. 2.Department of Rehabilitation Medicine, Icahn School of Medicine at Mount SinaiNew YorkUSA